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Park, Tae Joo
Developmental Morphogenesis Lab
Research Interests
  • Morphogenesis, chondrogenesis, ciliogenesis

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Identification and characterization of a putative homolog of a spliceosome component, precursor RNA processing 3 in Drosophila melanogaster

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Title
Identification and characterization of a putative homolog of a spliceosome component, precursor RNA processing 3 in Drosophila melanogaster
Author
Cho, SHPark, Tae JooAhnn, JSpoerel, NA
Issue Date
2002-10
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Citation
MOLECULES AND CELLS, v.14, no.2, pp.267 - 271
Abstract
Nuclear pre-mRNA splicing occurs in a large RNA-protein complex that contains four small nuclear ribonucleoprotein particles (snRNPs) as well as many protein factors. The Precursor RNA processing 3 (Prp3) is a U4/U6-associated splicing factor. A putative homologue of Prp3, which showed a 45% identity to the human Prp3 in an amino acid sequence, was identified in Drosophila melanogaster (dPrp3). A full-length cDNA clone was isolated and sequenced from the embryonic cDNA library. This gene consisted of 2 exons and contained an open-reading frame that encoded 550 amino acid residues. A Northern blot analysis showed that dPrp3 is expressed both maternally and zygotically. Immunostaining revealed that dPrp3 was localized to the nuclei of nurse cells and follicle cells in early embryos, which is consistent with its role as a component of spliceosome.
URI
https://scholarworks.unist.ac.kr/handle/201301/7201
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037206511
ISSN
1016-8478
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BIO_Journal Papers
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