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Park, Tae Joo
Developmental Morphogenesis Lab
Research Interests
  • Morphogenesis, chondrogenesis, ciliogenesis

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Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling

Cited 194 times inthomson ciCited 190 times inthomson ci
Title
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling
Author
Park, Tae JooHaigo, SLWallingford, JB
Issue Date
2006-03
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE GENETICS, v.38, no.3, pp.303 - 311
Abstract
The vertebrate planar cell polarity (PCP) pathway has previously been found to control polarized cell behaviors rather than cell fate. We report here that disruption of Xenopus laevis orthologs of the Drosophila melanogaster PCP effectors inturned (in) or fuzzy (fy) affected not only PCP-dependent convergent extension but also elicited embryonic phenotypes consistent with defective Hedgehog signaling. These defects in Hedgehog signaling resulted from a broad requirement for Inturned and Fuzzy in ciliogenesis. We show that these proteins govern apical actin assembly and thus control the orientation, but not assembly, of ciliary microtubules. Finally, accumulation of Dishevelled and Inturned near the basal apparatus of cilia suggests that these proteins function in a common pathway with core PCP components to regulate ciliogenesis. Together, these data highlight the interrelationships between cell polarity, cellular morphogenesis, signal transduction and cell fate specification.
URI
https://scholarworks.unist.ac.kr/handle/201301/7187
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33644624937
DOI
10.1038/ng1753
ISSN
1061-4036
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BIO_Journal Papers
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