BROWSE

Related Researcher

Author's Photo

Park, Jiyoung
Molecular Metabolism Laboratory (MML)
Research Interests
  • Obesity, diabetes, adipose tissue, cancer, cancer-associated adipocyte, dermal adipocyte, metabolic memory

ITEM VIEW & DOWNLOAD

Morphogenesis of the developing mammary gland: Stage-dependent impact of adipocytes

Cited 15 times inthomson ciCited 17 times inthomson ci
Title
Morphogenesis of the developing mammary gland: Stage-dependent impact of adipocytes
Author
Landskroner-Eiger, ShiraPark, JiyoungIsrael, DavelenePollard, Jeffrey W.Scherer, Philipp E.
Issue Date
2010-08
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
DEVELOPMENTAL BIOLOGY, v.344, no.2, pp.968 - 978
Abstract
Mammary gland development is critically dependent on the interactions between the stromal and the epithelial compartments within the gland. These events are under the control of a complex interplay of circulating and locally acting hormones and growth factors. To analyze the temporal and quantitative contributions of stromal adipocytes, we took advantage of the FAT-ATTAC mice (apoptosis through triggered activation of caspase-8), a model of inducible and reversible loss of adipocytes. This loss can be achieved through the induced dimerization of a caspase-8 fusion protein. In the context of female mice, we can achieve ablation of mammary adipocytes relatively selectively without affecting other fat pads. Under these conditions, we find that adipocytes are essential for the formation of the extended network of ducts in the mammary gland during puberty. Beyond their role in development, adipocytes are also essential to maintain the normal alveolar structures that develop during adulthood. Loss of adipose tissue initiated 2 weeks after birth triggers fewer duct branching points and fewer terminal end buds (TEBs) and also triggers changes in proliferation and apoptosis in the epithelium associated with the TEBs. The reduced developmental pace that adipocyte-ablated glands undergo is reversible, as the emergence of new local adipocytes, upon cessation of treatment, enables the ductal epithelium to resume growth. Conversely, loss of local adipocytes initiated at 7 weeks of age resulted in excessive lobulation, indicating that adipocytes are critically involved in maintaining proper architecture and functionality of the mammary epithelium. Collectively, using a unique model of inducible and reversible loss of adipocytes, our observations suggest that adipocytes are required for proper development during puberty and for the maintenance of the ductal architecture in the adult mammary gland.
URI
https://scholarworks.unist.ac.kr/handle/201301/7169
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955273404
DOI
10.1016/j.ydbio.2010.06.019
ISSN
0012-1606
Appears in Collections:
BIO_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU