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Park, Jiyoung
Molecular Metabolism Laboratory (MML)
Research Interests
  • Obesity, diabetes, adipose tissue, cancer, cancer-associated adipocyte, dermal adipocyte, metabolic memory

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Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression

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Title
Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression
Author
Park, JiyoungEuhus, David M.Scherer, Philipp E.
Keywords
ACTIVATED PROTEIN-KINASE;  TUMOR-NECROSIS-FACTOR;  3T3-L1 PREADIPOCYTE DIFFERENTIATION;  LEPTIN PROMOTES INVASIVENESS;  ENDOPLASMIC-RETICULUM STRESS;  SIGNAL-TRANSDUCTION PATHWAYS;  INDUCED INSULIN-RESISTANCE;  RECEPTOR-GAMMA ACTIVATION;  COLONIC EPITHELIAL-CELLS;  JUN NH2-TERMINAL KINASE
Issue Date
2011-08
Publisher
ENDOCRINE SOC
Citation
ENDOCRINE REVIEWS, v.32, no.4, pp.550 - 570
Abstract
The past few years have provided substantial evidence for the vital role of the local tumor microenvironment for various aspects of tumor progression. With obesity and its pathophysiological sequelae still on the rise, the adipocyte is increasingly moving center stage in the context of tumor stroma-related studies. To date, we have limited insight into how the systemic metabolic changes associated with obesity and the concomitant modification of the paracrine and endocrine panel of stromal adipocyte-derived secretory products ("adipokines") influence the incidence and progression of obesity-related cancers. Here, we discuss the role of adipocyte dysfunction associated with obesity and its potential impact on cancer biology.
URI
https://scholarworks.unist.ac.kr/handle/201301/7164
DOI
10.1210/er.2010-0030
ISSN
0163-769X
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