BROWSE

Related Researcher

Author's Photo

Park, Tae Joo
Developmental Morphogenesis Lab
Research Interests
  • Morphogenesis, chondrogenesis, ciliogenesis

ITEM VIEW & DOWNLOAD

Regulation of ciliary polarity by the APC/C

Cited 21 times inthomson ciCited 17 times inthomson ci
Title
Regulation of ciliary polarity by the APC/C
Author
Ganner, AthinaLienkamp, SoerenSchaefer, TobiasRomaker, DanielWegierski, TomaszPark, Tae JooSpreitzer, StefanSimons, MatiasGloy, JoachimKim, EmilyWallingford, John B.Walz, Gerd
Issue Date
2009-10
Publisher
NATL ACAD SCIENCES
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.106, no.42, pp.17799 - 17804
Abstract
Planar cell polarity signaling controls a variety of polarized cell behaviors. In multiciliated Xenopus epidermal cells, recruitment of Dishevelled (Dvl) to the basal body and its localization to the center of the ciliary rootlet are required to correctly position the motile cilia. We now report that the anaphase-promoting complex (APC/C) recognizes a D-box motif of Dvl and ubiquitylates Dvl on a highly conserved lysine residue. Inhibition of APC/C function by knockdown of the ANAPC2 subunit disrupts the polarity of motile cilia and alters the directionality of the fluid movement along the epidermis of the Xenopus embryo. Our results suggest that the APC/C activity enables cilia to correctly polarize in Xenopus epidermal cells.
URI
https://scholarworks.unist.ac.kr/handle/201301/7147
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70449570530
DOI
10.1073/pnas.0909465106
ISSN
0027-8424
Appears in Collections:
BIO_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU