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Kang, Byoung Heon
Cancer Biology Lab
Research Interests
  • Mitochondrial chaperones, cancer biology, cell death, metabolism, cancer stem cells, cancer therapeutics development

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Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein

Cited 47 times inthomson ciCited 46 times inthomson ci
Title
Regulation of survivin stability by the aryl hydrocarbon receptor-interacting protein
Author
Kang, Byoung HeonAltieri, Dario C.
Issue Date
2006-08
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Citation
JOURNAL OF BIOLOGICAL CHEMISTRY, v.281, no.34, pp.24721 - 24727
Abstract
Survivin is a multifunctional member of the IAP (inhibitor of apoptosis) family, but its molecular interactions in protection from cell death and regulation of cell division have not been completely elucidated. In a proteomics screening to identify novel survivin-binding partners, we found that the aryl hydrocarbon receptor-interacting protein (AIP) directly associates with survivin in vitro and in co-immunoprecipitation experiments in vivo. This interaction is mediated by the carboxyl-terminal end of AIP, which contains three tetratricopeptide motifs, and involves the carboxyl terminus coiled coil in survivin with critical roles of Asp142 in AIP recognition. A survivin mutant lacking only Asp142 fails to bind AIP and exhibits accelerated degradation in vivo in a reaction reversed by a proteasome inhibitor. Acute knock-down of AIP by short interference RNA or competition of the survivin-AIP complex by peptidyl mimicry destabilizes survivin levels in cells, with enhanced apoptosis but no changes in cell cycle progression. Therefore, AIP regulates survivin stability, thus elevating a cellular anti-apoptotic threshold. The survivin-AIP complex may influence the cellular xenobiotic response to environmental toxin(s) and contribute to subcellular chaperone trafficking during cell death regulation.
URI
https://scholarworks.unist.ac.kr/handle/201301/7112
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33747677470
DOI
10.1074/jbc.M603175200
ISSN
0021-9258
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BIO_Journal Papers
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