BROWSE

Related Researcher

Author's Photo

Ghim, Cheol-Min
Physical Biology & Biological Physics
Research Interests
  • Control of complex networks, Stochastic fluctuations in a cell, Biochemical information processing, Human microbiome, Ecological inference, Nonequilibrium active system

ITEM VIEW & DOWNLOAD

Physical model for the gating mechanism of ionic channels

Cited 3 times inthomson ciCited 3 times inthomson ci
Title
Physical model for the gating mechanism of ionic channels
Author
Ghim, Cheol-MinPark, JM
Issue Date
2002-11
Publisher
American Physical Society
Citation
PHYSICAL REVIEW E, v.66, no.5, pp.051910/1 - 051910/5
Abstract
We propose a physical model for the gating mechanism of ionic channels. First, we investigate the fluctuation-mediated interactions between two proteins imbedded in a cellular membrane and find that the interaction depends on their orientational configuration as well as the distance between them. The orientational dependence of interactions arises from the fact that the noncircular cross-sectional shapes of individual proteins constrain fluctuations of the membrane differently according to their orientational configuration. Then, we apply these interactions to ionic channels composed of four, five, and six proteins. As the gating stimulus creates the changes in the structural shape of proteins composing ionic channels, the orientational configuration of the ionic channels changes due to the free energy minimization, and ionic channels are open or closed according to the conformation thereof.
URI
https://scholarworks.unist.ac.kr/handle/201301/7100
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=37649030922
DOI
10.1103/PhysRevE.66.051910
ISSN
2470-0045
Appears in Collections:
PHY_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU