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Ghim, Cheol-Min
Physical Biology & Biological Physics
Research Interests
  • Control of complex networks, Stochastic fluctuations in a cell, Biochemical information processing, Human microbiome, Ecological inference, Nonequilibrium active system

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The Fixation Probability of Rare Mutators in Finite Asexual Populations

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Title
The Fixation Probability of Rare Mutators in Finite Asexual Populations
Author
Wylie, C. ScottGhim, Cheol-MinKessler, DavidLevine, Herbert
Issue Date
2009-04
Publisher
GENETICS SOC AM
Citation
GENETICS, v.181, no.4, pp.1595 - 1612
Abstract
A mutator is an allele that increases the mutation rate throughout the genome by disrupting some aspect of DNA replication or repair. Mutators that increase the mutation rate by the order of 100-fold have been observed to spontaneously emerge and achieve high frequencies in natural populations and in longterm laboratory evolution experiments with Escherichia coli. In principle, the fixation of mutator alleles is limited by (i) competition with mutations in wild-type backgrounds, (ii) additional deleterious mutational load, and (iii) random genetic drift. Using a multiple-locus model and employing both simulation and analytic methods, we investigate the effects of these three factors on the fixation probability Pfix of an initially rare mutator as a function of population size N, beneficial and deleterious mutation rates, and the strength of mutations s. Our diffusion-based approximation for Pfix successfully captures effects ii and iii when selection is fast compared to mutation (μ/s ≪1). This enables us to predict the conditions under which mutators will be evolutionarily favored. Surprisingly, our simulations show that effect i is typically small for strong-effect mutators. Our results agree semiquantitatively with existing laboratory evolution experiments and suggest future experimental directions.
URI
https://scholarworks.unist.ac.kr/handle/201301/7090
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67650314825
DOI
10.1534/genetics.108.094532
ISSN
0016-6731
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PHY_Journal Papers
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