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Ryu, Jungki
Bio-inspired Functional Materials Lab (BFML)
Research Interests
  • Biomimetics, artificial photosynthesis, biomimetic catalysis, CO2 utilization

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Mussel-inspired functionalization of carbon nanotubes for hydroxyapatite mineralization

Cited 27 times inthomson ciCited 22 times inthomson ci
Title
Mussel-inspired functionalization of carbon nanotubes for hydroxyapatite mineralization
Author
Lee, MinahKu, Sook HeeRyu, JungkiPark, Chan Beum
Keywords
BIOMEDICAL APPLICATIONS; BONE; COMPOSITES; COATINGS; SYSTEMS; APATITE
Issue Date
2010
Publisher
ROYAL SOC CHEMISTRY
Citation
JOURNAL OF MATERIALS CHEMISTRY, v.20, no.40, pp.8848 - 8853
Abstract
Hydroxyapatite (HAp)/carbon nanotubes (CNTs) hybrid composite materials are successfully synthesized via a biomineralization process that employs poly(dopamine) (PDA), a synthetic mimic of mussel adhesive proteins. Creating bio-inorganic composites for regenerative medicine requires appropriate fillers to enhance their mechanical robustness; for example, natural bones are composed mainly of HAp supported by collagen fibers. In this regard, many efforts have been made to harness HAp as a bone substitute through its integration with reinforcing fibrous materials such as CNTs. We found that the formation of a PDA ad-layer on the surface of CNTs changed the hydrophobic CNTs to become bioactive. This enabled efficient interaction between the CNTs and mineral ions (e.g., Ca2+), which facilitated the mineralization of HAp. CNTs functionalized with PDA (CNT-PDA) highly accelerated the formation of HAp when incubated in a simulated body fluid and exhibited a minimal cytotoxic effect on bone osteoblast cells compared to pristine or carboxylated CNTs. Our results show the potential of CNT-PDA as a scaffold material for bone tissue regeneration and implantation.
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DOI
10.1039/c0jm01339k
ISSN
0959-9428
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ECHE_Journal Papers
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