BROWSE

Related Researcher

Author's Photo

Kang, Sebyung
Protein Nanobio Lab
Research Interests
  • Protein engineering, Drug/diagnostics delivery nanoplatform, Protein-base vaccine delivery systems, Biosensor & imaging

ITEM VIEW & DOWNLOAD

A Streptavidin-Protein Cage Janus Particle for Polarized Targeting and Modular Functionalization

Cited 35 times inthomson ciCited 33 times inthomson ci
Title
A Streptavidin-Protein Cage Janus Particle for Polarized Targeting and Modular Functionalization
Author
Suci, Peter A.Kang, SebyungYoung, MarkDouglas, Trevor
Issue Date
2009-07
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.131, no.26, pp.9164 - 9165
Abstract
(Figure Presented) The incorporation of Janus particles into the repertoire of nanoscale building blocks adds a new level of control to supramolecular assembly. Here we demonstrate the potential for using toposelective modification to assemble new types of targeting nanoplatforms by docking the universal coupling protein, streptavidin (StAv), onto a restricted region of the surface of a small protein cage. The resulting StAv-functionalized Janus particles have the potential to be used to control the orientation of the nanoplatforms targeted to a cell surface. In addition, the StAv-biotin couple provides an ideal molecular adaptor for extending asymmetric (polarized) supramolecular assembly. To demonstrate this potential application, StAv-functionalized nanoplatforms were coupled to a biotinylated monoclonal antibody and used to target a microbial pathogen.
URI
https://scholarworks.unist.ac.kr/handle/201301/6442
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=67649970676
DOI
10.1021/ja9035187
ISSN
0002-7863
Appears in Collections:
BIO_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU