Life extension in Drosophila by feeding a drug
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- Life extension in Drosophila by feeding a drug
- Kang, HL; Benzer, S; Min, Kyung-Tai
- HISTONE DEACETYLASE; GENE-EXPRESSION; CAENORHABDITIS-ELEGANS; SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; EXTENDED LIFE; SPAN; MELANOGASTER; OVEREXPRESSION; MUTANT
- Issue Date
- NATL ACAD SCIENCES
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.99, no.2, pp.838 - 843
- We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.
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