dc.citation.endPage |
843 |
- |
dc.citation.number |
2 |
- |
dc.citation.startPage |
838 |
- |
dc.citation.title |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
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dc.citation.volume |
99 |
- |
dc.contributor.author |
Kang, HL |
- |
dc.contributor.author |
Benzer, S |
- |
dc.contributor.author |
Min, Kyung-Tai |
- |
dc.date.accessioned |
2023-12-22T11:40:14Z |
- |
dc.date.available |
2023-12-22T11:40:14Z |
- |
dc.date.created |
2014-09-15 |
- |
dc.date.issued |
2002-01 |
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dc.description.abstract |
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state. |
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dc.identifier.bibliographicCitation |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.99, no.2, pp.838 - 843 |
- |
dc.identifier.doi |
10.1073/pnas.022631999 |
- |
dc.identifier.issn |
0027-8424 |
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dc.identifier.scopusid |
2-s2.0-0037154205 |
- |
dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/6004 |
- |
dc.identifier.url |
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037154205 |
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dc.identifier.wosid |
000173450100055 |
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dc.language |
영어 |
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dc.publisher |
NATL ACAD SCIENCES |
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dc.title |
Life extension in Drosophila by feeding a drug |
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dc.type |
Article |
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dc.description.journalRegisteredClass |
scopus |
- |