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Myung, Kyungjae
Center for Genomic Integrity
Research Interests
  • DNA Replication, DNA Repair, DNA Recombination, DNA Damage Response, cancer, aging

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Crosstalk between different DNA repair pathways for DNA double strand break repairs

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Title
Crosstalk between different DNA repair pathways for DNA double strand break repairs
Author
Oh, Jung-MinMyung, Kyungjae
Issue Date
2022-01
Publisher
ELSEVIER
Citation
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v.873, pp.503438
Abstract
DNA double strand breaks (DSBs) are the most threatening type of DNA lesions and must be repaired properly in order to inhibit severe diseases and cell death. There are four major repair pathways for DSBs: non-homologous end joining (NHEJ), homologous recombination (HR), single strand annealing (SSA) and alternative end joining (alt-EJ). Cells choose repair pathway depending on the cell cycle phase and the length of 3; end of the DNA when DSBs are generated. Blunt and short regions of the 5; or 3; overhang DNA are repaired by NHEJ, which uses direct ligation or limited resection processing of the broken DNA end. In contrast, HR, SSA and alt-EJ use the resected DNA generated by the MRN (MRE11-RAD50-NBS1) complex and C-terminal binding protein interacting protein (CtIP) activated during the S and G2 phases. Here, we review recent findings on each repair pathway and the choice of repair mechanism and highlight the role of mismatch repair (MMR) protein in HR.
URI
https://scholarworks.unist.ac.kr/handle/201301/59333
URL
https://linkinghub.elsevier.com/retrieve/pii/S1383571821001297
DOI
10.1016/j.mrgentox.2021.503438
ISSN
1383-5718
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