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Kim, Gun-Ho
SoftHeat Group
Research Interests
  • Heat transfer mechanism in soft materials (e.g., plastics, animal tissues)
  • Development of thermally conductive plastics and high performance polymeric thermoelectric heat engine
  • Development of biomedical devices that use responses of animals to environmental temperature changes

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Effect of a Precision Cryotherapy Device with Temperature Adjustability on Pigmentation

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Title
Effect of a Precision Cryotherapy Device with Temperature Adjustability on Pigmentation
Author
Kwock, Mi HeeLee, SeongjinLee, Eun NyeHa, Gi UngKim, Gun-HoLee, Weon Ju
Issue Date
2022-03
Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
Citation
INDIAN JOURNAL OF DERMATOLOGY, v.67, no.2, pp.204
Abstract
Background: Pigmentary skin disorders impair the quality of life, leading to the development of therapeutic modalities. However, these treatments should focus more on effectiveness and safety. Aims and Objectives: To evaluate the effect of a temperature-adjustable cryotherapy device on the expression of pigmentation-related biomarkers. Methods and Results: A temperature- and time-adjustable cryotherapy device was employed to improve 200 mJ UVB-induced pigmentation on mice at -5 degrees C (for 5, 10 or 20 s), 0 degrees C (for 5, 10 or 20 s), 5 degrees C (for 5, 10 or 20 s), or 10 degrees C (for 5, 10 or 20 s). Expression of pigmentation-related biomarkers, such as tyrosinase, c-kit, melanocortin 1 receptor and microphthalmia-associated transcription factor before and after treatment with the cryotherapy device was investigated with real-time polymerase chain reaction and immunohistochemistry. Results: Expression of pigmentation-related biomarkers was decreased after the treatment of the temperature-adjustable cryotherapy device. Gene expression of the pigmentation-related biomarkers was decreased under the above conditions with some exception. Protein expression of the pigmentation-related biomarkers showed decreased tendency under the conditions with some exceptions. Conclusion: The temperature-adjustable cryotherapy device used in this study reduced the expression of pigmentation-related biomarkers on mice and may be used to treat patients with skin pigmentation.
URI
https://scholarworks.unist.ac.kr/handle/201301/59332
DOI
10.4103/ijd.ijd_755_21
ISSN
0019-5154
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