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DC Field | Value | Language |
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dc.citation.number | 2 | - |
dc.citation.startPage | 204 | - |
dc.citation.title | INDIAN JOURNAL OF DERMATOLOGY | - |
dc.citation.volume | 67 | - |
dc.contributor.author | Kwock, Mi Hee | - |
dc.contributor.author | Lee, Seongjin | - |
dc.contributor.author | Lee, Eun Nye | - |
dc.contributor.author | Ha, Gi Ung | - |
dc.contributor.author | Kim, Gun-Ho | - |
dc.contributor.author | Lee, Weon Ju | - |
dc.date.accessioned | 2023-12-21T14:21:30Z | - |
dc.date.available | 2023-12-21T14:21:30Z | - |
dc.date.created | 2022-09-08 | - |
dc.date.issued | 2022-03 | - |
dc.description.abstract | Background: Pigmentary skin disorders impair the quality of life, leading to the development of therapeutic modalities. However, these treatments should focus more on effectiveness and safety. Aims and Objectives: To evaluate the effect of a temperature-adjustable cryotherapy device on the expression of pigmentation-related biomarkers. Methods and Results: A temperature- and time-adjustable cryotherapy device was employed to improve 200 mJ UVB-induced pigmentation on mice at -5 degrees C (for 5, 10 or 20 s), 0 degrees C (for 5, 10 or 20 s), 5 degrees C (for 5, 10 or 20 s), or 10 degrees C (for 5, 10 or 20 s). Expression of pigmentation-related biomarkers, such as tyrosinase, c-kit, melanocortin 1 receptor and microphthalmia-associated transcription factor before and after treatment with the cryotherapy device was investigated with real-time polymerase chain reaction and immunohistochemistry. Results: Expression of pigmentation-related biomarkers was decreased after the treatment of the temperature-adjustable cryotherapy device. Gene expression of the pigmentation-related biomarkers was decreased under the above conditions with some exception. Protein expression of the pigmentation-related biomarkers showed decreased tendency under the conditions with some exceptions. Conclusion: The temperature-adjustable cryotherapy device used in this study reduced the expression of pigmentation-related biomarkers on mice and may be used to treat patients with skin pigmentation. | - |
dc.identifier.bibliographicCitation | INDIAN JOURNAL OF DERMATOLOGY, v.67, no.2, pp.204 | - |
dc.identifier.doi | 10.4103/ijd.ijd_755_21 | - |
dc.identifier.issn | 0019-5154 | - |
dc.identifier.scopusid | 2-s2.0-85135118818 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/59332 | - |
dc.identifier.wosid | 000838720600036 | - |
dc.language | 영어 | - |
dc.publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS | - |
dc.title | Effect of a Precision Cryotherapy Device with Temperature Adjustability on Pigmentation | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Cryotherapy device | - |
dc.subject.keywordAuthor | pigmentation | - |
dc.subject.keywordAuthor | UVB | - |
dc.subject.keywordPlus | HUMAN-SKIN | - |
dc.subject.keywordPlus | NEVUS OTA | - |
dc.subject.keywordPlus | MELANOSOME | - |
dc.subject.keywordPlus | KERATINOCYTES | - |
dc.subject.keywordPlus | MELANOCYTES | - |
dc.subject.keywordPlus | BIOLOGY | - |
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