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A Glycosylated Prodrug to Attenuate Neuroinflammation and Improve Cognitive Deficits in Alzheimer's Disease Transgenic Mice
- Author(s)
- Kim, Mingeun, Park, Min Hee, Nam, Geewoo, Lee, Misun, Kang, Juhye, Song, Im-Sook, Choi, Min-Koo, Jin, Hee Kyung, Bae, Jae-Sung, Lim, Mi Hee
- Issued Date
- 2021-01
- Citation
- MOLECULAR PHARMACEUTICS, v.18, no.1, pp.101 - 112
- Abstract
- We report a prodrug, Glu-DAPPD, to overcome the shortcomings of an anti-neuroinflammatory molecule, N,N'-diacetyl-p-phenylenediamine (DAPPD), in biological applicability for potential therapeutic applications. We suspect that Glu-DAPPD can release DAPPD through endogenous enzymatic bioconversion. Consequently, Glu-DAPPD exhibits in vivo efficacies in alleviating neuroinflammation, reducing amyloid-beta aggregate accumulation, and improving cognitive function in Alzheimer's disease transgenic mice. Our studies demonstrate that the prodrug approach is suitable and effective toward developing drug candidates against neurodegeneration.
- Publisher
- AMER CHEMICAL SOC
- ISSN
- 1543-8384
- Keyword (Author)
- Alzheimer&apos, s disease, prodrug, anti-neuroinflammation, microglial function, amyloid-beta
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