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| DC Field | Value | Language |
|---|---|---|
| dc.citation.endPage | 112 | - |
| dc.citation.number | 1 | - |
| dc.citation.startPage | 101 | - |
| dc.citation.title | MOLECULAR PHARMACEUTICS | - |
| dc.citation.volume | 18 | - |
| dc.contributor.author | Kim, Mingeun | - |
| dc.contributor.author | Park, Min Hee | - |
| dc.contributor.author | Nam, Geewoo | - |
| dc.contributor.author | Lee, Misun | - |
| dc.contributor.author | Kang, Juhye | - |
| dc.contributor.author | Song, Im-Sook | - |
| dc.contributor.author | Choi, Min-Koo | - |
| dc.contributor.author | Jin, Hee Kyung | - |
| dc.contributor.author | Bae, Jae-Sung | - |
| dc.contributor.author | Lim, Mi Hee | - |
| dc.date.accessioned | 2023-12-21T16:19:46Z | - |
| dc.date.available | 2023-12-21T16:19:46Z | - |
| dc.date.created | 2022-01-12 | - |
| dc.date.issued | 2021-01 | - |
| dc.description.abstract | We report a prodrug, Glu-DAPPD, to overcome the shortcomings of an anti-neuroinflammatory molecule, N,N'-diacetyl-p-phenylenediamine (DAPPD), in biological applicability for potential therapeutic applications. We suspect that Glu-DAPPD can release DAPPD through endogenous enzymatic bioconversion. Consequently, Glu-DAPPD exhibits in vivo efficacies in alleviating neuroinflammation, reducing amyloid-beta aggregate accumulation, and improving cognitive function in Alzheimer's disease transgenic mice. Our studies demonstrate that the prodrug approach is suitable and effective toward developing drug candidates against neurodegeneration. | - |
| dc.identifier.bibliographicCitation | MOLECULAR PHARMACEUTICS, v.18, no.1, pp.101 - 112 | - |
| dc.identifier.doi | 10.1021/acs.molpharmaceut.0c00677 | - |
| dc.identifier.issn | 1543-8384 | - |
| dc.identifier.scopusid | 2-s2.0-85097750576 | - |
| dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/56607 | - |
| dc.identifier.url | https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.0c00677 | - |
| dc.identifier.wosid | 000606803900008 | - |
| dc.language | 영어 | - |
| dc.publisher | AMER CHEMICAL SOC | - |
| dc.title | A Glycosylated Prodrug to Attenuate Neuroinflammation and Improve Cognitive Deficits in Alzheimer's Disease Transgenic Mice | - |
| dc.type | Article | - |
| dc.description.isOpenAccess | FALSE | - |
| dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental; Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Research & Experimental Medicine; Pharmacology & Pharmacy | - |
| dc.type.docType | Article | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.subject.keywordAuthor | Alzheimer&apos | - |
| dc.subject.keywordAuthor | s disease | - |
| dc.subject.keywordAuthor | prodrug | - |
| dc.subject.keywordAuthor | anti-neuroinflammation | - |
| dc.subject.keywordAuthor | microglial function | - |
| dc.subject.keywordAuthor | amyloid-beta | - |
| dc.subject.keywordPlus | ARYLAMINE N-ACETYLTRANSFERASES | - |
| dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
| dc.subject.keywordPlus | MICROGLIAL DYSFUNCTION | - |
| dc.subject.keywordPlus | BETA-GLUCOSIDASES | - |
| dc.subject.keywordPlus | SPECIFICITY | - |
| dc.subject.keywordPlus | TARGET | - |
| dc.subject.keywordPlus | METABOLISM | - |
| dc.subject.keywordPlus | CLEARANCE | - |
| dc.subject.keywordPlus | MECHANISM | - |
| dc.subject.keywordPlus | PROTEIN | - |
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