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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics

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The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins

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Title
The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins
Author
Park, JooriChang, JeeyoonHwang, Hyun JungJeong, KwonLee, Hyuk-JoonHa, HongseokPark, YeonkyoungLim, ChunghunWoo, Jae-SungKim, Yoon Ki
Issue Date
2021-12
Publisher
OXFORD UNIV PRESS
Citation
NUCLEIC ACIDS RESEARCH, v.49, no.21, pp.12517 - 12534
Abstract
The pioneer (or first) round of translation of newly synthesized mRNAs is largely mediated by a nuclear cap-binding complex (CBC). In a transcriptome-wide analysis of polysome-associated and CBC-bound transcripts, we identify RN7SL1, a noncoding RNA component of a signal recognition particle (SRP), as an interaction partner of the CBC. The direct CBC–SRP interaction safeguards against abnormal expression of polypeptides from a ribosome–nascent chain complex (RNC)–SRP complex until the latter is properly delivered to the endoplasmic reticulum. Failure of this surveillance causes abnormal expression of misfolded proteins at inappropriate intracellular locations, leading to a cytosolic stress response. This surveillance pathway also blocks protein synthesis through RNC–SRP misassembled on an mRNA encoding a mitochondrial protein. Thus, our results reveal a surveillance pathway in which pioneer translation ensures proper targeting of endoplasmic reticulum and mitochondrial proteins.
URI
https://scholarworks.unist.ac.kr/handle/201301/54953
URL
https://academic.oup.com/nar/article/49/21/12517/6439695
DOI
10.1093/nar/gkab1098
ISSN
0305-1048
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BIO_Journal Papers
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