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Lim, Chunghun
Neurogenetics & Ribonomics Laboratory (The Lim Lab)
Research Interests
  • Ribosome Biology, Translation, Neurodegeneration, Behavioral Genetics

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The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins

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dc.contributor.author Park, Joori ko
dc.contributor.author Chang, Jeeyoon ko
dc.contributor.author Hwang, Hyun Jung ko
dc.contributor.author Jeong, Kwon ko
dc.contributor.author Lee, Hyuk-Joon ko
dc.contributor.author Ha, Hongseok ko
dc.contributor.author Park, Yeonkyoung ko
dc.contributor.author Lim, Chunghun ko
dc.contributor.author Woo, Jae-Sung ko
dc.contributor.author Kim, Yoon Ki ko
dc.date.available 2021-12-02T08:10:32Z -
dc.date.created 2021-12-01 ko
dc.date.issued 2021-12 ko
dc.identifier.citation NUCLEIC ACIDS RESEARCH, v.49, no.21, pp.12517 - 12534 ko
dc.identifier.issn 0305-1048 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/54953 -
dc.description.abstract The pioneer (or first) round of translation of newly synthesized mRNAs is largely mediated by a nuclear cap-binding complex (CBC). In a transcriptome-wide analysis of polysome-associated and CBC-bound transcripts, we identify RN7SL1, a noncoding RNA component of a signal recognition particle (SRP), as an interaction partner of the CBC. The direct CBC–SRP interaction safeguards against abnormal expression of polypeptides from a ribosome–nascent chain complex (RNC)–SRP complex until the latter is properly delivered to the endoplasmic reticulum. Failure of this surveillance causes abnormal expression of misfolded proteins at inappropriate intracellular locations, leading to a cytosolic stress response. This surveillance pathway also blocks protein synthesis through RNC–SRP misassembled on an mRNA encoding a mitochondrial protein. Thus, our results reveal a surveillance pathway in which pioneer translation ensures proper targeting of endoplasmic reticulum and mitochondrial proteins. ko
dc.language 영어 ko
dc.publisher OXFORD UNIV PRESS ko
dc.title The pioneer round of translation ensures proper targeting of ER and mitochondrial proteins ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85122294945 ko
dc.identifier.wosid 000733312000039 ko
dc.type.rims ART ko
dc.identifier.doi 10.1093/nar/gkab1098 ko
dc.identifier.url https://academic.oup.com/nar/article/49/21/12517/6439695 ko
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