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박종남

Park, Jongnam
Materials and Chemistry Lab.
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Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo

Author(s)
Choi, YuriKim, SeongchanChoi, Myung-HoRyoo, Soo-RyoonPark, JongnamMin, Dal-HeeKim, Byeong-Su
Issued Date
2014-10
DOI
10.1002/adfm.201400961
URI
https://scholarworks.unist.ac.kr/handle/201301/5405
Fulltext
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907702311
Citation
ADVANCED FUNCTIONAL MATERIALS, v.24, no.37, pp.5781 - 5789
Abstract
Photosensitizers (PSs) are light-sensitive molecules that are highly hydrophobic, which poses a challenge to their use for targeted photodynamic therapy. Hence, considerable efforts have been made to develop carriers for the delivery of PSs. Herein, a novel design is described of highly biocompatible, fluorescent, folic acid (FA)-functionalized carbon nanodots (CDs) as carriers for the PS zinc phthalocyanine (ZnPc) to achieve simultaneous biological imaging and targeted photodynamic therapy. FA is modified on PEG--passivated CDs (CD-PEG) for targeted delivery to FA-positive cancer cells, and ZnPc is loaded onto CD-PEG-FA via π-π stacking interactions. CD-PEG-FA/ZnPc exhibits excellent targeted delivery of the PS, leading to simultaneous imaging and significant targeted photodynamic therapy after irradiation in vitro and in vivo. The present CD-based targeted delivery of PSs is anticipated to offer a convenient and effective platform for enhanced photodynamic therapy to treat cancers in the near future.
Publisher
WILEY-V C H VERLAG GMBH
ISSN
1616-301X

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