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Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications

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Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo

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Title
Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo
Author
Choi, YuriKim, SeongchanChoi, Myung-HoRyoo, Soo-RyoonPark, JongnamMin, Dal-HeeKim, Byeong-Su
Issue Date
2014-10
Publisher
WILEY-V C H VERLAG GMBH
Citation
ADVANCED FUNCTIONAL MATERIALS, v.24, no.37, pp.5781 - 5789
Abstract
Photosensitizers (PSs) are light-sensitive molecules that are highly hydrophobic, which poses a challenge to their use for targeted photodynamic therapy. Hence, considerable efforts have been made to develop carriers for the delivery of PSs. Herein, a novel design is described of highly biocompatible, fluorescent, folic acid (FA)-functionalized carbon nanodots (CDs) as carriers for the PS zinc phthalocyanine (ZnPc) to achieve simultaneous biological imaging and targeted photodynamic therapy. FA is modified on PEG--passivated CDs (CD-PEG) for targeted delivery to FA-positive cancer cells, and ZnPc is loaded onto CD-PEG-FA via π-π stacking interactions. CD-PEG-FA/ZnPc exhibits excellent targeted delivery of the PS, leading to simultaneous imaging and significant targeted photodynamic therapy after irradiation in vitro and in vivo. The present CD-based targeted delivery of PSs is anticipated to offer a convenient and effective platform for enhanced photodynamic therapy to treat cancers in the near future.
URI
https://scholarworks.unist.ac.kr/handle/201301/5405
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907702311
DOI
10.1002/adfm.201400961
ISSN
1616-301X
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BME_Journal Papers
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