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Kim, Byeong-Su
Soft and Hybrid Nanomaterials Lab
Research Interests
  • Carbon materials, polymer, Layer-by-Layer (LbL) assembly, hyperbranched polymer, polyglycerol (PG), bio-applications

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Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo

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dc.contributor.author Choi, Yuri ko
dc.contributor.author Kim, Seongchan ko
dc.contributor.author Choi, Myung-Ho ko
dc.contributor.author Ryoo, Soo-Ryoon ko
dc.contributor.author Park, Jongnam ko
dc.contributor.author Min, Dal-Hee ko
dc.contributor.author Kim, Byeong-Su ko
dc.date.available 2014-08-11T08:37:57Z -
dc.date.created 2014-08-11 ko
dc.date.issued 2014-10 ko
dc.identifier.citation ADVANCED FUNCTIONAL MATERIALS, v.24, no.37, pp.5781 - 5789 ko
dc.identifier.issn 1616-301X ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5405 -
dc.description.abstract Photosensitizers (PSs) are light-sensitive molecules that are highly hydrophobic, which poses a challenge to their use for targeted photodynamic therapy. Hence, considerable efforts have been made to develop carriers for the delivery of PSs. Herein, a novel design is described of highly biocompatible, fluorescent, folic acid (FA)-functionalized carbon nanodots (CDs) as carriers for the PS zinc phthalocyanine (ZnPc) to achieve simultaneous biological imaging and targeted photodynamic therapy. FA is modified on PEG--passivated CDs (CD-PEG) for targeted delivery to FA-positive cancer cells, and ZnPc is loaded onto CD-PEG-FA via π-π stacking interactions. CD-PEG-FA/ZnPc exhibits excellent targeted delivery of the PS, leading to simultaneous imaging and significant targeted photodynamic therapy after irradiation in vitro and in vivo. The present CD-based targeted delivery of PSs is anticipated to offer a convenient and effective platform for enhanced photodynamic therapy to treat cancers in the near future. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher WILEY-V C H VERLAG GMBH ko
dc.title Highly Biocompatible Carbon Nanodots for Simultaneous Bioimaging and Targeted Photodynamic Therapy In Vitro and In Vivo ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84941036373 ko
dc.identifier.wosid 000342794500001 ko
dc.type.rims ART ko
dc.description.wostc 4 *
dc.description.scopustc 0 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-08-11 *
dc.identifier.doi 10.1002/adfm.201400961 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907702311 ko
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