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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Application of self-assembly peptides targeting the mitochondria as a novel treatment for sorafenib-resistant hepatocellular carcinoma cells

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Title
Application of self-assembly peptides targeting the mitochondria as a novel treatment for sorafenib-resistant hepatocellular carcinoma cells
Author
Hong, Tae HoJeena, M. T.Kim, Ok-HeeKim, Kee-HwanChoi, Ho JoongLee, Kyung HeeHong, Ha-EunRyu, Ja-HyoungKim, Say-June
Issue Date
2021-01
Publisher
NATURE RESEARCH
Citation
SCIENTIFIC REPORTS, v.11, no.1, pp.874
Abstract
Currently, there is no appropriate treatment option for patients with sorafenib-resistant hepatocellular carcinoma (HCC). Meanwhile, pronounced anticancer activities of newly-developed mitochondria-accumulating self-assembly peptides (Mito-FF) have been demonstrated. This study intended to determine the anticancer effects of Mito-FF against sorafenib-resistant Huh7 (Huh7-R) cells. Compared to sorafenib, Mito-FF led to the generation of relatively higher amounts of mitochondrial reactive oxygen species (ROS) as well as the greater reduction in the expression of antioxidant enzymes (P < 0.05). Mito-FF was found to significantly promote cell apoptosis while inhibiting cell proliferation of Huh7-R cells. Mito-FF also reduces the expression of antioxidant enzymes while significantly increasing mitochondrial ROS in Huh7-R cells. The pro-apoptotic effect of Mito-FFs for Huh7-R cells is possibly caused by their up-regulation of mitochondrial ROS, which is caused by the destruction of the mitochondria of HCC cells.
URI
https://scholarworks.unist.ac.kr/handle/201301/52674
URL
https://www.nature.com/articles/s41598-020-79536-z
DOI
10.1038/s41598-020-79536-z
ISSN
2045-2322
Appears in Collections:
CHM_Journal Papers
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