Full metadata record
DC Field | Value | Language |
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dc.citation.number | 1 | - |
dc.citation.startPage | 874 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Hong, Tae Ho | - |
dc.contributor.author | Jeena, M. T. | - |
dc.contributor.author | Kim, Ok-Hee | - |
dc.contributor.author | Kim, Kee-Hwan | - |
dc.contributor.author | Choi, Ho Joong | - |
dc.contributor.author | Lee, Kyung Hee | - |
dc.contributor.author | Hong, Ha-Eun | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.contributor.author | Kim, Say-June | - |
dc.date.accessioned | 2023-12-21T16:21:34Z | - |
dc.date.available | 2023-12-21T16:21:34Z | - |
dc.date.created | 2021-04-05 | - |
dc.date.issued | 2021-01 | - |
dc.description.abstract | Currently, there is no appropriate treatment option for patients with sorafenib-resistant hepatocellular carcinoma (HCC). Meanwhile, pronounced anticancer activities of newly-developed mitochondria-accumulating self-assembly peptides (Mito-FF) have been demonstrated. This study intended to determine the anticancer effects of Mito-FF against sorafenib-resistant Huh7 (Huh7-R) cells. Compared to sorafenib, Mito-FF led to the generation of relatively higher amounts of mitochondrial reactive oxygen species (ROS) as well as the greater reduction in the expression of antioxidant enzymes (P < 0.05). Mito-FF was found to significantly promote cell apoptosis while inhibiting cell proliferation of Huh7-R cells. Mito-FF also reduces the expression of antioxidant enzymes while significantly increasing mitochondrial ROS in Huh7-R cells. The pro-apoptotic effect of Mito-FFs for Huh7-R cells is possibly caused by their up-regulation of mitochondrial ROS, which is caused by the destruction of the mitochondria of HCC cells. | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.11, no.1, pp.874 | - |
dc.identifier.doi | 10.1038/s41598-020-79536-z | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.scopusid | 2-s2.0-85099409021 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/52674 | - |
dc.identifier.url | https://www.nature.com/articles/s41598-020-79536-z | - |
dc.identifier.wosid | 000621765000027 | - |
dc.language | 영어 | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Application of self-assembly peptides targeting the mitochondria as a novel treatment for sorafenib-resistant hepatocellular carcinoma cells | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.subject.keywordPlus | NANOMATERIALS | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | ROS | - |
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