Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 6 | - |
dc.citation.startPage | 31479 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 22 | - |
dc.contributor.author | Kim, Hye Yun | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.date.accessioned | 2023-12-21T16:10:55Z | - |
dc.date.available | 2023-12-21T16:10:55Z | - |
dc.date.created | 2021-03-25 | - |
dc.date.issued | 2021-03 | - |
dc.description.abstract | Epilepsy is characterized by recurrent seizures due to abnormal hyperexcitation of neurons. Recent studies have suggested that the imbalance of excitation and inhibition (E/I) in the central nervous system is closely implicated in the etiology of epilepsy. In the brain, GABA is a major inhibitory neurotransmitter and plays a pivotal role in maintaining E/I balance. As such, altered GABAergic inhibition can lead to severe E/I imbalance, consequently resulting in excessive and hypersynchronous neuronal activity as in epilepsy. Phospholipase C (PLC) is a key enzyme in the intracellular signaling pathway and regulates various neuronal functions including neuronal development, synaptic transmission, and plasticity in the brain. Accumulating evidence suggests that neuronal PLC is critically involved in multiple aspects of GABAergic functions. Therefore, a better understanding of mechanisms by which neuronal PLC regulates GABAergic inhibition is necessary for revealing an unrecognized linkage between PLC and epilepsy and developing more effective treatments for epilepsy. Here we review the function of PLC in GABAergic inhibition in the brain and discuss a pathophysiological relationship between PLC and epilepsy. | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.6, pp.31479 | - |
dc.identifier.doi | 10.3390/ijms22063149 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.scopusid | 2-s2.0-85102683899 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/50559 | - |
dc.identifier.url | https://www.mdpi.com/1422-0067/22/6/3149 | - |
dc.identifier.wosid | 000645735100001 | - |
dc.language | 영어 | - |
dc.publisher | MDPI | - |
dc.title | The role of phospholipase C in gabaergic inhibition and its relevance to epilepsy | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Chemistry | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | -aminobutyric acid (GABA) | - |
dc.subject.keywordAuthor | excitatory | - |
dc.subject.keywordAuthor | inhibitory balance (E | - |
dc.subject.keywordAuthor | I balance) | - |
dc.subject.keywordAuthor | GABAergic inhibition | - |
dc.subject.keywordAuthor | epilepsy | - |
dc.subject.keywordAuthor | Phospholipase C (PLC) | - |
dc.subject.keywordAuthor | γ | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.