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Suh, Pann-Ghill
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dc.citation.number 6 -
dc.citation.startPage 31479 -
dc.citation.title INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -
dc.citation.volume 22 -
dc.contributor.author Kim, Hye Yun -
dc.contributor.author Suh, Pann-Ghill -
dc.contributor.author Kim, Jae-Ick -
dc.date.accessioned 2023-12-21T16:10:55Z -
dc.date.available 2023-12-21T16:10:55Z -
dc.date.created 2021-03-25 -
dc.date.issued 2021-03 -
dc.description.abstract Epilepsy is characterized by recurrent seizures due to abnormal hyperexcitation of neurons. Recent studies have suggested that the imbalance of excitation and inhibition (E/I) in the central nervous system is closely implicated in the etiology of epilepsy. In the brain, GABA is a major inhibitory neurotransmitter and plays a pivotal role in maintaining E/I balance. As such, altered GABAergic inhibition can lead to severe E/I imbalance, consequently resulting in excessive and hypersynchronous neuronal activity as in epilepsy. Phospholipase C (PLC) is a key enzyme in the intracellular signaling pathway and regulates various neuronal functions including neuronal development, synaptic transmission, and plasticity in the brain. Accumulating evidence suggests that neuronal PLC is critically involved in multiple aspects of GABAergic functions. Therefore, a better understanding of mechanisms by which neuronal PLC regulates GABAergic inhibition is necessary for revealing an unrecognized linkage between PLC and epilepsy and developing more effective treatments for epilepsy. Here we review the function of PLC in GABAergic inhibition in the brain and discuss a pathophysiological relationship between PLC and epilepsy. -
dc.identifier.bibliographicCitation INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.6, pp.31479 -
dc.identifier.doi 10.3390/ijms22063149 -
dc.identifier.issn 1661-6596 -
dc.identifier.scopusid 2-s2.0-85102683899 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/50559 -
dc.identifier.url https://www.mdpi.com/1422-0067/22/6/3149 -
dc.identifier.wosid 000645735100001 -
dc.language 영어 -
dc.publisher MDPI -
dc.title The role of phospholipase C in gabaergic inhibition and its relevance to epilepsy -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology; Chemistry, Multidisciplinary -
dc.relation.journalResearchArea Biochemistry & Molecular Biology; Chemistry -
dc.type.docType Review -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor -aminobutyric acid (GABA) -
dc.subject.keywordAuthor excitatory -
dc.subject.keywordAuthor inhibitory balance (E -
dc.subject.keywordAuthor I balance) -
dc.subject.keywordAuthor GABAergic inhibition -
dc.subject.keywordAuthor epilepsy -
dc.subject.keywordAuthor Phospholipase C (PLC) -
dc.subject.keywordAuthor γ -

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