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Park, Sunghoon
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Recent Progress in the Understanding and Engineering of Coenzyme B-12-Dependent Glycerol Dehydratase

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Title
Recent Progress in the Understanding and Engineering of Coenzyme B-12-Dependent Glycerol Dehydratase
Author
Nasir, AbdulAshok, SomasundarShim, Jeung YeopPark, SunghoonYoo, Tae Hyeon
Issue Date
2020-11
Publisher
FRONTIERS MEDIA SA
Citation
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v.8, pp.500867
Abstract
Coenzyme B-12-dependent glycerol dehydratase (GDHt) catalyzes the dehydration reaction of glycerol in the presence of adenosylcobalamin to yield 3-hydroxypropanal (3-HPA), which can be converted biologically to versatile platform chemicals such as 1,3-propanediol and 3-hydroxypropionic acid. Owing to the increased demand for biofuels, developing biological processes based on glycerol, which is a byproduct of biodiesel production, has attracted considerable attention recently. In this review, we will provide updates on the current understanding of the catalytic mechanism and structure of coenzyme B-12-dependent GDHt, and then summarize the results of engineering attempts, with perspectives on future directions in its engineering.
URI
https://scholarworks.unist.ac.kr/handle/201301/49294
URL
https://www.frontiersin.org/articles/10.3389/fbioe.2020.500867/full
DOI
10.3389/fbioe.2020.500867
ISSN
2296-4185
Appears in Collections:
ECHE_Journal Papers
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