Recent Progress in the Understanding and Engineering of Coenzyme B-12-Dependent Glycerol Dehydratase
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- Recent Progress in the Understanding and Engineering of Coenzyme B-12-Dependent Glycerol Dehydratase
- Nasir, Abdul; Ashok, Somasundar; Shim, Jeung Yeop; Park, Sunghoon; Yoo, Tae Hyeon
- Issue Date
- FRONTIERS MEDIA SA
- FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v.8, pp.500867
- Coenzyme B-12-dependent glycerol dehydratase (GDHt) catalyzes the dehydration reaction of glycerol in the presence of adenosylcobalamin to yield 3-hydroxypropanal (3-HPA), which can be converted biologically to versatile platform chemicals such as 1,3-propanediol and 3-hydroxypropionic acid. Owing to the increased demand for biofuels, developing biological processes based on glycerol, which is a byproduct of biodiesel production, has attracted considerable attention recently. In this review, we will provide updates on the current understanding of the catalytic mechanism and structure of coenzyme B-12-dependent GDHt, and then summarize the results of engineering attempts, with perspectives on future directions in its engineering.
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