Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission
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- Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission
- Kim, Sangpil; Kim, Juhee; Jana, Batakrishna; Ryu, Ja-Hyoung
- Issue Date
- ROYAL SOC CHEMISTRY
- RSC Advances, v.10, no.71, pp.43383 - 43388
- Controlled intracellular chemical reactions to regulate cellular functions remain a challenge in biology mimetic systems. Herein, we developed an intra-mitochondrial bio-orthogonal reaction to induce aggregation induced emission. In situ carbonyl ligation inside mitochondria drives the molecules to form nano-aggregates with green fluorescence, which leads to depolarization of the mitochondrial membrane, generation of ROS, and subsequently mitochondrial dysfunction. This intra-mitochondrial carbonyl ligation shows great potential for anticancer treatment in various cancer cell lines.
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- CHM_Journal Papers
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