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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission

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Title
Intra-mitochondrial reaction for cancer cell imaging and anti-cancer therapy by aggregation-induced emission
Author
Kim, SangpilKim, JuheeJana, BatakrishnaRyu, Ja-Hyoung
Issue Date
2020-12
Publisher
ROYAL SOC CHEMISTRY
Citation
RSC Advances, v.10, no.71, pp.43383 - 43388
Abstract
Controlled intracellular chemical reactions to regulate cellular functions remain a challenge in biology mimetic systems. Herein, we developed an intra-mitochondrial bio-orthogonal reaction to induce aggregation induced emission. In situ carbonyl ligation inside mitochondria drives the molecules to form nano-aggregates with green fluorescence, which leads to depolarization of the mitochondrial membrane, generation of ROS, and subsequently mitochondrial dysfunction. This intra-mitochondrial carbonyl ligation shows great potential for anticancer treatment in various cancer cell lines.
URI
https://scholarworks.unist.ac.kr/handle/201301/48991
URL
https://pubs.rsc.org/en/content/articlelanding/2020/RA/D0RA07471C#!divAbstract
DOI
10.1039/d0ra07471c
ISSN
2046-2069
Appears in Collections:
CHM_Journal Papers
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