BROWSE

Related Researcher

Author's Photo

Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability

ITEM VIEW & DOWNLOAD

OSMOREGULATION OF NA+-INOSITOL COTRANSPORTER ACTIVITY AND MESSENGER-RNA LEVELS IN BRAIN GLIAL-CELLS

Cited 75 times inthomson ciCited 62 times inthomson ci
Title
OSMOREGULATION OF NA+-INOSITOL COTRANSPORTER ACTIVITY AND MESSENGER-RNA LEVELS IN BRAIN GLIAL-CELLS
Author
PAREDES, AMCMANUS, MKwon, H. MooSTRANGE, K
Issue Date
1992-12
Publisher
American Physiological Society
Citation
AMERICAN JOURNAL OF PHYSIOLOGY, v.263, no.6, pp.C1282 - C1288
Abstract
During plasma hypertonicity brain volume is regulated acutely by electrolyte uptake and chronically by accumulation of organic solutes such as inositol. Cultured rat C6 glioma cells, an astrocyte-like cell line, show a similar pattern of volume control. Volume regulatory accumulation of inositol requires external inositol, indicating that membrane transport plays a central role in this process. The inositol uptake pathway is Na+ dependent and exhibits Michaelis-Menten kinetics. Chronic hypertonic acclimation results in a twofold increase in the maximum velocity of the transporter without changing the K(m). Hypertonic stress also results in a 17-fold increase in transporter mRNA. Elevation of mRNA levels precedes activation of the transporter by 4-6 h, suggesting that increased inositol uptake is mediated by synthesis and membrane insertion of new transport proteins. Reacclimation of hypertonic cells to isotonicity causes a rapid reduction of transporter mRNA levels to control levels within 4 h. In contrast, downregulation of transport activity does not begin until between 10 and 24 h after reexposure to isotonicity.
URI
https://scholarworks.unist.ac.kr/handle/201301/4863
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027043129
ISSN
0002-9513
Appears in Collections:
BIO_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU