단면이 규칙적으로 변하는 미세유체 채널을 이용한 유전영동 기반의 박테리아 분리 장치에 대한 3D 시뮬레이션

Abstract

Dielectrophoresis is one of the most effective technologies for separating a species of particle or cell from a heterogeneous bioparticle mixture in a microfluidic channel. If the frequency of an applied AC voltage is tuned properly, targeted particles can be concentrated in the device while the others thrown away due to the opposite direction of the applied dielectrophoretic forces between them. In this study, a 2D planar microelectrode pattern is located on the bottom, and the targeted bacteria are forced to move downward periodically due to the changing cross-sectional areas, thereby the bacteria concentrated on the electrodes. We conducted a 3D simulation of particle tracing with respect to the flow rate, and the applied peak-to-peak voltage for the calculation of particle collection efficiencies of the bacteria in the device, and we compared with those of the conventional microseparator.