O-GlcNAcylation in cellular functions and human diseases
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- O-GlcNAcylation in cellular functions and human diseases
- Yang, Yong Ryoul; Suh, Pann-Ghill
- Issue Date
- ELSEVIER BV
- ADVANCES IN BIOLOGICAL REGULATION, v.54, no.1, pp.68 - 73
- O-GlcNAcylation is dynamic and a ubiquitous post-translational modification. O-GlcNAcylated proteins influence fundamental functions of proteins such as protein-protein interactions, altering protein stability, and changing protein activity. Thus, aberrant regulation of O-GlcNAcylation contributes to the etiology of chronic diseases of aging, including cancer, cardiovascular disease, metabolic disorders, and Alzheimer's disease. Diverse cellular signaling systems are involved in pathogenesis of these diseases. O-GlcNAcylated proteins occur in many different tissues and cellular compartments and affect specific cell signaling. This review focuses on the O-GlcNAcylation in basic cellular functions and human diseases.
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