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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Natural polypeptide-based supramolecular nanogels for stable noncovalent encapsulation

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Title
Natural polypeptide-based supramolecular nanogels for stable noncovalent encapsulation
Author
Kim, KeunsukBae, BoramKang, Young JiNam, Jwa-MinKang, SebyungRyu, Ja-Hyoung
Keywords
DRUG-DELIVERY SYSTEMS; CELL-PENETRATING PEPTIDES; IN-VITRO; NANOPARTICLES; RELEASE; NANOCARRIERS; PROTEINS; BIODEGRADATION; POLYMERIZATION; HYDROGELS
Issue Date
2013-10
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.14, no.10, pp.3515 - 3522
Abstract
Supramolecular nanogel, a physically cross-linked nanosize hydrogel, spontaneously self-assembles in aqueous solution via secondary interactions and is thus of great interest in nanomedicine as a drug carrier. We developed a versatile method for supramolecular nanogel self-assembled by electrostatic interaction between positive surfactant micelles and negative polypeptides. Core-shell-like structures of supramolecular nanogels provide stable hydrophobic pockets that prevent simple diffusion of hydrophobic guest molecules, resulting in high encapsulation stability. The size of the supramolecular nanogels can be systematically controlled by varying the size of the surfactant micelles. Furthermore, noncovalently encapsulated dye molecules can be released in response to matrix metalloproteinases highly overexpressed in tumor tissues, potentially providing tumor-triggered targeting.
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DOI
10.1021/bm400846h
ISSN
1525-7797
Appears in Collections:
PHY_Journal Papers
BME_Journal Papers
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