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Hong, Sung You
Synthetic Organic Chemistry Laboratory
Research Interests
  • Synthetic organic chemistry, transition metals, oxidation state

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Polyvalent display of monosaccharides on ferritin protein cage nanoparticles for the recognition and binding of cell-surface lectins

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Title
Polyvalent display of monosaccharides on ferritin protein cage nanoparticles for the recognition and binding of cell-surface lectins
Author
Kang, Young JiYang, Hyun JiJeon, SangbinKang, Young-SunDo, YoonkyungHong, Sung YouKang, Sebyung
Issue Date
2014-05
Publisher
WILEY-V C H VERLAG GMBH
Citation
MACROMOLECULAR BIOSCIENCE, v.14, no.5, pp.619 - 625
Abstract
Carbohydrate-lectin interactions are important in many biological events. Endogenous cell-surface lectins are attractive markers for the recognition and targeting. Human ferritin protein cage nanoparticles (HFPCNs) are prepared as delivery nanoplatforms and two different types of monosaccharide derivatives; maleimido group terminated-mannopyranoside and galactopyranoside. Uniform and polyvalent displays of mannoses or galactoses on the surface of HFPCNs are achieved by using site-specific thiol-maleimide Michael-type addition. Mannose- or galactose-displaying HFPCNs recognize and tightly bind to DC-SIGN or ASGP-R lectins on the surface of the mammalian cells, DCEK or HepG2 cells.
URI
https://scholarworks.unist.ac.kr/handle/201301/4099
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84901001229
DOI
10.1002/mabi.201300528
ISSN
1616-5187
Appears in Collections:
BIO_Journal Papers
CHM_Journal Papers
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