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Kwon, Tae-Hyuk
Energy Recognition
Research Interests
  • Energy transfer, organic solar cells, supercapacitor, ultrasonic spray chemistry, dithienothiophene, iridium complexes, phosphorescent bioapplications

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MOF × Biopolymer: Collaborative Combination of Metal–Organic Framework and Biopolymer for Advanced Anticancer Therapy

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Title
MOF × Biopolymer: Collaborative Combination of Metal–Organic Framework and Biopolymer for Advanced Anticancer Therapy
Author
Kim, KibeomLee, SungminJin, EunjiPalanikumar, L.Lee, Jeong HyeonKim, Jin ChulNam, Jung SeungJana, BatakrishnaKwon, Tae-HyukKwak, Sang KyuChoe, WonyoungRyu, Ja-Hyoung
Issue Date
2019-08
Publisher
American Chemical Society
Citation
ACS APPLIED MATERIALS & INTERFACES, v.11, no.31, pp.27512 - 27520
Abstract
Metal-organic framework (MOF) nanoparticles with high porosity and greater tunability have emerged as new drug delivery vehicles. However, premature drug release still remains a challenge in the MOF delivery system. Here, we report an enzyme-responsive, polymer-coated MOF gatekeeper system using hyaluronic acid (HA) and PCN-224 nanoMOF. The external surface of nanoMOF can be stably covered by HA through multivalent coordination bonding between the Zr cluster and carboxylic acid of HA, which acts as a gatekeeper. HA allows selective accumulation of drug carriers in CD44 overexpressed cancer cells and enzyme-responsive drug release in the cancer cell environment. In particular, inherent characteristics of PCN-224, which is used as a drug carrier, facilitates the transfer of the drug to cancer cells more stably and allows photodynamic therapy. This HA-PCN system enables a dual chemo and photodynamic therapy to enhance the cancer therapy effect.
URI
https://scholarworks.unist.ac.kr/handle/201301/33043
URL
https://pubs.acs.org/doi/abs/10.1021/acsami.9b05736
DOI
10.1021/acsami.9b05736
ISSN
1944-8244
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CHM_Journal Papers
ECHE_Journal Papers
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