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DC Field | Value | Language |
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dc.citation.endPage | 27520 | - |
dc.citation.number | 31 | - |
dc.citation.startPage | 27512 | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 11 | - |
dc.contributor.author | Kim, Kibeom | - |
dc.contributor.author | Lee, Sungmin | - |
dc.contributor.author | Jin, Eunji | - |
dc.contributor.author | Palanikumar, L. | - |
dc.contributor.author | Lee, Jeong Hyeon | - |
dc.contributor.author | Kim, Jin Chul | - |
dc.contributor.author | Nam, Jung Seung | - |
dc.contributor.author | Jana, Batakrishna | - |
dc.contributor.author | Kwon, Tae-Hyuk | - |
dc.contributor.author | Kwak, Sang Kyu | - |
dc.contributor.author | Choe, Wonyoung | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.date.accessioned | 2023-12-21T18:48:04Z | - |
dc.date.available | 2023-12-21T18:48:04Z | - |
dc.date.created | 2020-07-07 | - |
dc.date.issued | 2019-08 | - |
dc.description.abstract | Metal-organic framework (MOF) nanoparticles with high porosity and greater tunability have emerged as new drug delivery vehicles. However, premature drug release still remains a challenge in the MOF delivery system. Here, we report an enzyme-responsive, polymer-coated MOF gatekeeper system using hyaluronic acid (HA) and PCN-224 nanoMOF. The external surface of nanoMOF can be stably covered by HA through multivalent coordination bonding between the Zr cluster and carboxylic acid of HA, which acts as a gatekeeper. HA allows selective accumulation of drug carriers in CD44 overexpressed cancer cells and enzyme-responsive drug release in the cancer cell environment. In particular, inherent characteristics of PCN-224, which is used as a drug carrier, facilitates the transfer of the drug to cancer cells more stably and allows photodynamic therapy. This HA-PCN system enables a dual chemo and photodynamic therapy to enhance the cancer therapy effect. | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.11, no.31, pp.27512 - 27520 | - |
dc.identifier.doi | 10.1021/acsami.9b05736 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.scopusid | 2-s2.0-85070577713 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/33043 | - |
dc.identifier.url | https://pubs.acs.org/doi/abs/10.1021/acsami.9b05736 | - |
dc.identifier.wosid | 000480498600003 | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | MOF × Biopolymer: Collaborative Combination of Metal–Organic Framework and Biopolymer for Advanced Anticancer Therapy | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | metal-organic framework | - |
dc.subject.keywordAuthor | gatekeeper system | - |
dc.subject.keywordAuthor | colloidal stability | - |
dc.subject.keywordAuthor | cancer targeting | - |
dc.subject.keywordAuthor | combined therapy | - |
dc.subject.keywordPlus | MESOPOROUS SILICA NANOPARTICLES | - |
dc.subject.keywordPlus | TARGETED DRUG-DELIVERY | - |
dc.subject.keywordPlus | RATIONAL DESIGN | - |
dc.subject.keywordPlus | PLATFORM | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | CONSTRUCTION | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | SIZE | - |
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