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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells

Cited 11 times inthomson ciCited 7 times inthomson ci
Title
Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells
Author
Lim, SeyoungJang, Hyun-JunPark, Eun HeeKim, Jung KukKim, Jung-MinKim, Eung-KyunYea, KyungmooKim, Yun-HeeLee-Kwon, WhaseonRyu, Sung HoSuh, Pann-Ghill
Keywords
ADIPOGENESIS; MESENCHYMAL STEM CELLS; WEDELOLACTONE
Issue Date
2012-11
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF CELLULAR BIOCHEMISTRY, v.113, no.11, pp.3436 - 3445
Abstract
Wedelolactone is an herbal medicine that is used to treat septic shock, hepatitis and venom poisoning. Although in differentiated and cancer cells, wedelolactone has been identified as anti-inflammatory, growth inhibitory, and pro-apoptotic, the effects of wedelolactone on stem cell differentiation remain largely unknown. Here, we report that wedelolactone inhibits the adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells (hAMSCs). Wedelolactone reduced the formation of lipid droplets and the expression of adipogenesis-related proteins, such as CCAAT enhancer-binding protein-a (C/EBP-a), peroxisome proliferator-activated receptor-? (PPAR-?), lipoprotein lipase (LPL), and adipocyte fatty acid-binding protein aP2 (aP2). Wedelolactone mediated this process by sustaining ERK activity. In addition, inhibition of ERK activity with PD98059 resulted in reversion of the wedelolactone-mediated inhibition of adipogenic differentiation. Taken together, these results indicate that wedelolactone inhibits adipogenic differentiation through ERK pathway and suggest a novel inhibitory effect of wedelolactone on adipogenic differentiation in hAMSCs.
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DOI
10.1002/jcb.24220
ISSN
0730-2312
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