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DC Field | Value | Language |
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dc.citation.endPage | 3445 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3436 | - |
dc.citation.title | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.citation.volume | 113 | - |
dc.contributor.author | Lim, Seyoung | - |
dc.contributor.author | Jang, Hyun-Jun | - |
dc.contributor.author | Park, Eun Hee | - |
dc.contributor.author | Kim, Jung Kuk | - |
dc.contributor.author | Kim, Jung-Min | - |
dc.contributor.author | Kim, Eung-Kyun | - |
dc.contributor.author | Yea, Kyungmoo | - |
dc.contributor.author | Kim, Yun-Hee | - |
dc.contributor.author | Lee-Kwon, Whaseon | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T04:38:26Z | - |
dc.date.available | 2023-12-22T04:38:26Z | - |
dc.date.created | 2013-06-04 | - |
dc.date.issued | 2012-11 | - |
dc.description.abstract | Wedelolactone is an herbal medicine that is used to treat septic shock, hepatitis and venom poisoning. Although in differentiated and cancer cells, wedelolactone has been identified as anti-inflammatory, growth inhibitory, and pro-apoptotic, the effects of wedelolactone on stem cell differentiation remain largely unknown. Here, we report that wedelolactone inhibits the adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells (hAMSCs). Wedelolactone reduced the formation of lipid droplets and the expression of adipogenesis-related proteins, such as CCAAT enhancer-binding protein-a (C/EBP-a), peroxisome proliferator-activated receptor-? (PPAR-?), lipoprotein lipase (LPL), and adipocyte fatty acid-binding protein aP2 (aP2). Wedelolactone mediated this process by sustaining ERK activity. In addition, inhibition of ERK activity with PD98059 resulted in reversion of the wedelolactone-mediated inhibition of adipogenic differentiation. Taken together, these results indicate that wedelolactone inhibits adipogenic differentiation through ERK pathway and suggest a novel inhibitory effect of wedelolactone on adipogenic differentiation in hAMSCs. | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR BIOCHEMISTRY, v.113, no.11, pp.3436 - 3445 | - |
dc.identifier.doi | 10.1002/jcb.24220 | - |
dc.identifier.issn | 0730-2312 | - |
dc.identifier.scopusid | 2-s2.0-84866503308 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/2866 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84866503308 | - |
dc.identifier.wosid | 000308927200014 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells | - |
dc.type | Article | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | ADIPOGENESIS | - |
dc.subject.keywordAuthor | MESENCHYMAL STEM CELLS | - |
dc.subject.keywordAuthor | WEDELOLACTONE | - |
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