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Ryu, Ja-Hyoung
Supramolecular NanoMaterials Lab (SUN)
Research Interests
  • Supramolecular assembly, synthetic peptide assembly, cancer drug delivery

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Mitochondrial Heat Shock Protein-Guided Photodynamic Therapy

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Title
Mitochondrial Heat Shock Protein-Guided Photodynamic Therapy
Author
Thomas, Ajesh P.Lee, An-JungPalanikumar, LJana, BatakrishnaKim, KibeomKim, SangpilOk, HaewonSeol, JihoonKim, DongseokKang, Byoung HeonRyu, Ja-Hyoung
Issue Date
2019-10
Publisher
Royal Society of Chemistry
Citation
CHEMICAL COMMUNICATIONS, v.55, no.84, pp.12631 - 12634
Abstract
Mitochondria targeting sensitizers are continuing to gain importance in photodynamic therapy (PDT). Members of the 90 KDa heat shock protein (Hsp90) family, including TRAP1 (Hsp75), are overexpressed in cancer cells and help to control the antiapoptotic protein activity. The present work introduces an Hsp90 inhibitor-mitochondria targeting indocyanine dye conjugate (IR-PU) for high PDT efficacy
URI
https://scholarworks.unist.ac.kr/handle/201301/27781
URL
https://pubs.rsc.org/en/Content/ArticleLanding/2019/CC/C9CC06411G#!divAbstract
DOI
10.1039/C9CC06411G
ISSN
1359-7345
Appears in Collections:
CHM_Journal Papers
BIO_Journal Papers
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