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Nam, Dougu
Statistical Genomics Lab
Research Interests
  • Gene network, pathway analysis, biclustering, disease classification

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GSA-SNP: a general approach for gene set analysis of polymorphisms

Cited 39 times inthomson ciCited 40 times inthomson ci
Title
GSA-SNP: a general approach for gene set analysis of polymorphisms
Author
Nam, DouguKim, JinKim, Seon-YoungKim, Sangsoo
Keywords
GENOME-WIDE ASSOCIATION; ENRICHMENT ANALYSIS; ADULT HEIGHT; TRAITS; VARIANTS; PATHWAYS; DISEASES; LINKAGE; LOCI
Issue Date
2010-07
Publisher
OXFORD UNIV PRESS
Citation
NUCLEIC ACIDS RESEARCH, v.38, no., pp.W749 - W754
Abstract
Genome-wide association (GWA) study aims to identify the genetic factors associated with the traits of interest. However, the power of GWA analysis has been seriously limited by the enormous number of markers tested. Recently, the gene set analysis (GSA) methods were introduced to GWA studies to address the association of gene sets that share common biological functions. GSA considerably increased the power of association analysis and successfully identified coordinated association patterns of gene sets. There have been several approaches in this direction with some limitations. Here, we present a general approach for GSA in GWA analysis and a stand-alone software GSA-SNP that implements three widely used GSA methods. GSA-SNP provides a fast computation and an easy-to-use interface. The software and test datasets are freely available at http://gsa.muldas.org. We provide an exemplary analysis on adult heights in a Korean population.
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DOI
10.1093/nar/gkq428
ISSN
0305-1048
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SLS_Journal Papers
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