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Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(II)-amyloid-beta
- Author(s)
- Yi, Yelim, Han, Jiyeon, Park, Min Hee, Park, Nahye, Nam, Eunju, Jin, Hee Kyung, Bae, Jae-Sung, Lim, Mi Hee
- Issued Date
- 2019-05
- Citation
- CHEMICAL COMMUNICATIONS, v.55, no.42, pp.5847 - 5850
- Abstract
- We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(II)bound amyloid-beta [ Zn(II)-A beta], two pathological targets found in the brain affected by Alzheimer's disease. Rational tuning of the hydrophobicity and Zn(II) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(II)-A beta (phen, 1, and 2), or both (3).
- Publisher
- ROYAL SOC CHEMISTRY
- ISSN
- 1359-7345
- Keyword
- AMYLOID-BETA-PEPTIDE, A-BETA, ALZHEIMERS, SPECTROSCOPY, MECHANISMS, DISEASE, SYSTEM, ZINC
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