Detailed Information
Cited time in 
Cited time in 
Cited time in
Metadata Downloads
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.citation.endPage | 5850 | - |
| dc.citation.number | 42 | - |
| dc.citation.startPage | 5847 | - |
| dc.citation.title | CHEMICAL COMMUNICATIONS | - |
| dc.citation.volume | 55 | - |
| dc.contributor.author | Yi, Yelim | - |
| dc.contributor.author | Han, Jiyeon | - |
| dc.contributor.author | Park, Min Hee | - |
| dc.contributor.author | Park, Nahye | - |
| dc.contributor.author | Nam, Eunju | - |
| dc.contributor.author | Jin, Hee Kyung | - |
| dc.contributor.author | Bae, Jae-Sung | - |
| dc.contributor.author | Lim, Mi Hee | - |
| dc.date.accessioned | 2023-12-21T19:09:50Z | - |
| dc.date.available | 2023-12-21T19:09:50Z | - |
| dc.date.created | 2019-06-10 | - |
| dc.date.issued | 2019-05 | - |
| dc.description.abstract | We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(II)bound amyloid-beta [ Zn(II)-A beta], two pathological targets found in the brain affected by Alzheimer's disease. Rational tuning of the hydrophobicity and Zn(II) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(II)-A beta (phen, 1, and 2), or both (3). | - |
| dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.55, no.42, pp.5847 - 5850 | - |
| dc.identifier.doi | 10.1039/c9cc01005j | - |
| dc.identifier.issn | 1359-7345 | - |
| dc.identifier.scopusid | 2-s2.0-85065985813 | - |
| dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/26885 | - |
| dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC01005J#!divAbstract | - |
| dc.identifier.wosid | 000468478100029 | - |
| dc.language | 영어 | - |
| dc.publisher | ROYAL SOC CHEMISTRY | - |
| dc.title | Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(II)-amyloid-beta | - |
| dc.type | Article | - |
| dc.description.isOpenAccess | FALSE | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.type.docType | Article | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.subject.keywordPlus | AMYLOID-BETA-PEPTIDE | - |
| dc.subject.keywordPlus | A-BETA | - |
| dc.subject.keywordPlus | ALZHEIMERS | - |
| dc.subject.keywordPlus | SPECTROSCOPY | - |
| dc.subject.keywordPlus | MECHANISMS | - |
| dc.subject.keywordPlus | DISEASE | - |
| dc.subject.keywordPlus | SYSTEM | - |
| dc.subject.keywordPlus | ZINC | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.