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Jung, Woonggyu
Translational Biophotonics Laboratory (TBL)
Research Interests
  • Translational optical imaging, optical stimulation, multi-scale imaging, neuro-photonics, mobile-based medical device

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Mouse neuroblastoma cell-based model and the effect of epileptic events on calcium oscillations and neural spikes

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Title
Mouse neuroblastoma cell-based model and the effect of epileptic events on calcium oscillations and neural spikes
Author
Kim, SuhwanJung, UnsangBaek, JuyoungLee, SangwonJung, WoonggyuKim, JeehyunKang, Shinwon
Keywords
mouse neuroblastoma cell; epilepsy; calcium oscillation; neural spikes
Issue Date
2013-11
Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
Citation
JOURNAL OF NANOPHOTONICS, v.7, no.1, pp.073794 -
Abstract
Recently, mouse neuroblastoma cells have been considered as an attractive model for the study of human neurological and prion diseases, and they have been intensively used as a model system in different areas. For example, the differentiation of neuro2a (N2A) cells, receptor-mediated ion current, and glutamate-induced physiological responses have been actively investigated with these cells. These mouse neuroblastoma N2A cells are of interest because they grow faster than other cells of neural origin and have a number of other advantages. The calcium oscillations and neural spikes of mouse neuroblastoma N2A cells in epileptic conditions are evaluated. Based on our observations of neural spikes in these cells with our proposed imaging modality, we reported that they can be an important model in epileptic activity studies. We concluded that mouse neuroblastoma N2A cells produce epileptic spikes in vitro in the same way as those produced by neurons or astrocytes. This evidence suggests that increased levels of neurotransmitter release due to the enhancement of free calcium from 4-aminopyridine causes the mouse neuroblastoma N2A cells to produce epileptic spikes and calcium oscillations.
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DOI
10.1117/1.JNP.7.073794
ISSN
1934-2608
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SLS_Journal Papers
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