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Jung, Woonggyu
Translational Biophotonics Laboratory (TBL)
Research Interests
  • Translational optical imaging, optical stimulation, multi-scale imaging, neuro-photonics, mobile-based medical device

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Mouse neuroblastoma cell-based model and the effect of epileptic events on calcium oscillations and neural spikes

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dc.contributor.author Kim, Suhwan ko
dc.contributor.author Jung, Unsang ko
dc.contributor.author Baek, Juyoung ko
dc.contributor.author Lee, Sangwon ko
dc.contributor.author Jung, Woonggyu ko
dc.contributor.author Kim, Jeehyun ko
dc.contributor.author Kang, Shinwon ko
dc.date.available 2014-04-09T08:28:11Z -
dc.date.created 2013-12-04 ko
dc.date.issued 2013-11 -
dc.identifier.citation JOURNAL OF NANOPHOTONICS, v.7, no.1, pp.073794 - ko
dc.identifier.issn 1934-2608 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/2606 -
dc.identifier.uri http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84888150486 ko
dc.description.abstract Recently, mouse neuroblastoma cells have been considered as an attractive model for the study of human neurological and prion diseases, and they have been intensively used as a model system in different areas. For example, the differentiation of neuro2a (N2A) cells, receptor-mediated ion current, and glutamate-induced physiological responses have been actively investigated with these cells. These mouse neuroblastoma N2A cells are of interest because they grow faster than other cells of neural origin and have a number of other advantages. The calcium oscillations and neural spikes of mouse neuroblastoma N2A cells in epileptic conditions are evaluated. Based on our observations of neural spikes in these cells with our proposed imaging modality, we reported that they can be an important model in epileptic activity studies. We concluded that mouse neuroblastoma N2A cells produce epileptic spikes in vitro in the same way as those produced by neurons or astrocytes. This evidence suggests that increased levels of neurotransmitter release due to the enhancement of free calcium from 4-aminopyridine causes the mouse neuroblastoma N2A cells to produce epileptic spikes and calcium oscillations. ko
dc.description.statementofresponsibility open -
dc.language ENG ko
dc.publisher SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS ko
dc.subject mouse neuroblastoma cell ko
dc.subject epilepsy ko
dc.subject calcium oscillation ko
dc.subject neural spikes ko
dc.title Mouse neuroblastoma cell-based model and the effect of epileptic events on calcium oscillations and neural spikes ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84888150486 ko
dc.identifier.wosid 000326492200002 ko
dc.type.rims ART ko
dc.description.wostc 0 *
dc.description.scopustc 0 *
dc.date.tcdate 2015-02-28 *
dc.date.scptcdate 2014-07-12 *
dc.identifier.doi 10.1117/1.JNP.7.073794 ko
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