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Jang, Jaesung
Sensors & Aerosols Lab
Research Interests
  • Bio-MEMS

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Lipid-Hydrogel-Nanostructure Hybrids as Robust Biofilm-Resistant Polymeric Materials

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Title
Lipid-Hydrogel-Nanostructure Hybrids as Robust Biofilm-Resistant Polymeric Materials
Author
Park, Hyun-HaSun, KahyunSeong, MinhoM. KangPark, SunhoPark, SeongkyeolJung, HosupJang, JaesungKim, JanghoJeong, Hoon Eui
Issue Date
2019-01
Publisher
AMER CHEMICAL SOC
Citation
ACS MACRO LETTERS, v.8, no.1, pp.64 - 69
Abstract
Despite extensive efforts toward developing antibiofilm materials, efficient prevention of biofilm formation remains challenging. Approaches based on a single strategy using either bactericidal material, antifouling coatings, or nanopatterning have shown limited performance in the prevention of biofilm formation. This study presents a hybrid strategy based on a lipid-hydrogel-nanotopography hybrid for the development of a highly efficient and durable biofilm-resistant material. The hybrid material consists of nanostructured antifouling, biocompatible polyethylene glycol-based polymer grafted with an antifouling zwitterionic polymer of 2-methacryloyloxyethyl phosphorylcholine. Based on the unique composite nanostructures, the lipid-hydrogel-nanostructure hybrid exhibits superior dual functionalities of antifouling and bactericidal activities against Gram-negative and Gram-positive bacteria, compared with those of surfaces with simple nanostructures or antifouling coatings. Additionally, it preserves the robust antibiofilm activity even when the material is damaged under external mechanical stimuli thanks to the polymeric composite nanostructure.
URI
https://scholarworks.unist.ac.kr/handle/201301/25752
URL
https://pubs.acs.org/doi/10.1021/acsmacrolett.8b00888
DOI
10.1021/acsmacrolett.8b00888
ISSN
2161-1653
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