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Kim, Jiyun
School of Materials Science and Engineering
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One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening

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Title
One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening
Author
Song, Seo WooKim, Su DeokOh, Dong YoonLee, YongjuLee, Amos ChungwonJeong, YunjinBae, Hyung JongLee, DaewonLee, SuminKim, JiyunKwon, Sunghoon
Issue Date
2019-02
Publisher
WILEY
Citation
ADVANCED SCIENCE, v.6, no.3, pp.1801380
Abstract
Large-scale screening of sequential drug combinations, wherein the dynamic rewiring of intracellular pathways leads to promising therapeutic effects and improvements in quality of life, is essential for personalized medicine to ensure realistic cost and time requirements and less sample consumption. However, the large-scale screening requires expensive and complicated liquid handling systems for automation and therefore lowers the accessibility to clinicians or biologists, limiting the full potential of sequential drug combinations in clinical applications and academic investigations. Here, a miniaturized platform for high-throughput combinatorial drug screening that is "pipetting-free" and scalable for the screening of sequential drug combinations is presented. The platform uses parallel and bottom-up formation of a heterogeneous drug-releasing hydrogel microarray by self-assembly of drug-laden hydrogel microparticles. This approach eliminates the need for liquid handling systems and time-consuming operation in high-throughput large-scale screening. In addition, the serial replacement of the drug-releasing microarray-on-a-chip facilitates different drug exchange in each and every microwell in a simple and highly parallel manner, supporting scalable implementation of multistep combinatorial screening. The proposed strategy can be applied to various forms of combinatorial drug screening with limited amounts of samples and resources, which will broaden the use of the large-scale screening for precision medicine.
URI
https://scholarworks.unist.ac.kr/handle/201301/25683
URL
https://onlinelibrary.wiley.com/doi/10.1002/advs.201801380
DOI
10.1002/advs.201801380
ISSN
2198-3844
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MSE_Journal Papers
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