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The Interface Between ER and Mitochondria: Molecular Compositions and Functions

Author(s)
Lee, SoyeonMin, Kyung-Tai
Issued Date
2018-12
DOI
10.14348/molcells.2018.0438
URI
https://scholarworks.unist.ac.kr/handle/201301/25506
Fulltext
http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2018.0438
Citation
MOLECULES AND CELLS, v.41, no.12, pp.1000 - 1007
Abstract
Mitochondria and endoplasmic reticulum (ER) are essential organelles in eukaryotic cells, which play key roles in various biological pathways. Mitochondria are responsible for ATP production, maintenance of Ca2+ homeostasis and regulation of apoptosis, while ER is involved in protein folding, lipid metabolism as well as Ca2+ homeostasis. These organelles have their own functions, but they also communicate via mitochondrial-associated ER membrane (MAM) to provide another level of regulations in energy production, lipid process, Ca2+ buffering, and apoptosis. Hence, defects in MAM alter cell survival and death. Here, we review components forming the molecular junctions of MAM and how MAM regulates cellular functions. Furthermore, we discuss the effects of impaired ER-mitochondrial communication in various neurodegenerative diseases.
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
ISSN
1016-8478
Keyword (Author)
ER-mitochondria tetheringmitochondrial-associated ER membrane (MAM)neurodegenerative disease
Keyword
ENDOPLASMIC-RETICULUMALZHEIMERS-DISEASESIGMA-1 RECEPTORBINDING-PROTEINLIPID-TRANSFERCONTACT SITESCYTOCHROME-CPRESENILIN 2CA2+MEMBRANES

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