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Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • adult neurogenesis; axon development; axon regeneration; protein stability; protein synthesis; Down syndrome; Alzheimer's disease;

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The Interface Between ER and Mitochondria: Molecular Compositions and Functions

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Title
The Interface Between ER and Mitochondria: Molecular Compositions and Functions
Author
Lee, SoyeonMin, Kyung-Tai
Issue Date
2018-12
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Citation
MOLECULES AND CELLS, v.41, no.12, pp.1000 - 1007
Abstract
Mitochondria and endoplasmic reticulum (ER) are essential organelles in eukaryotic cells, which play key roles in various biological pathways. Mitochondria are responsible for ATP production, maintenance of Ca2+ homeostasis and regulation of apoptosis, while ER is involved in protein folding, lipid metabolism as well as Ca2+ homeostasis. These organelles have their own functions, but they also communicate via mitochondrial-associated ER membrane (MAM) to provide another level of regulations in energy production, lipid process, Ca2+ buffering, and apoptosis. Hence, defects in MAM alter cell survival and death. Here, we review components forming the molecular junctions of MAM and how MAM regulates cellular functions. Furthermore, we discuss the effects of impaired ER-mitochondrial communication in various neurodegenerative diseases.
URI
https://scholarworks.unist.ac.kr/handle/201301/25506
URL
http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2018.0438
DOI
10.14348/molcells.2018.0438
ISSN
1016-8478
Appears in Collections:
SLS_Journal Papers
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