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Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • adult neurogenesis; axon development; axon regeneration; protein stability; protein synthesis; Down syndrome; Alzheimer's disease;

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The Interface Between ER and Mitochondria: Molecular Compositions and Functions

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dc.contributor.author Lee, Soyeon ko
dc.contributor.author Min, Kyung-Tai ko
dc.date.available 2018-12-21T00:35:16Z -
dc.date.created 2018-12-18 ko
dc.date.issued 2018-12 ko
dc.identifier.citation MOLECULES AND CELLS, v.41, no.12, pp.1000 - 1007 ko
dc.identifier.issn 1016-8478 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/25506 -
dc.description.abstract Mitochondria and endoplasmic reticulum (ER) are essential organelles in eukaryotic cells, which play key roles in various biological pathways. Mitochondria are responsible for ATP production, maintenance of Ca2+ homeostasis and regulation of apoptosis, while ER is involved in protein folding, lipid metabolism as well as Ca2+ homeostasis. These organelles have their own functions, but they also communicate via mitochondrial-associated ER membrane (MAM) to provide another level of regulations in energy production, lipid process, Ca2+ buffering, and apoptosis. Hence, defects in MAM alter cell survival and death. Here, we review components forming the molecular junctions of MAM and how MAM regulates cellular functions. Furthermore, we discuss the effects of impaired ER-mitochondrial communication in various neurodegenerative diseases. ko
dc.language 영어 ko
dc.publisher KOREAN SOC MOLECULAR & CELLULAR BIOLOGY ko
dc.title The Interface Between ER and Mitochondria: Molecular Compositions and Functions ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-85059231350 ko
dc.identifier.wosid 000454506000002 ko
dc.type.rims ART ko
dc.identifier.doi 10.14348/molcells.2018.0438 ko
dc.identifier.url http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2018.0438 ko
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