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김홍태

Kim, Hongtae
Cancer/DNA damage Lab.
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Factors forming the BRCA1-A complex orchestrate BRCA1 recruitment to the sites of DNA damage

Author(s)
Her, JoonyoungLee, Nam SooKim, YonghwanKim, Hongtae
Issued Date
2016-07
DOI
10.1093/abbs/gmw047
URI
https://scholarworks.unist.ac.kr/handle/201301/24879
Fulltext
https://academic.oup.com/abbs/article/48/7/658/2236652
Citation
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, v.48, no.7, pp.658 - 664
Abstract
Sustaining genomic integrity is essential for preventing onset of cancers. Therefore, human cells evolve to have refined biological pathways to defend genetic materials from various genomic insults. DNA damage response and DNA repair pathways essential for genome maintenance are accomplished by cooperative executions of multiple factors including breast cancer type 1 susceptibility protein (BRCA1). BRCA1 is initially identified as an altered gene in the hereditary breast cancer patients. Since then, tremendous efforts to understand the functions of BRAC1 reveal that BRCA1 is found in distinct complexes, including BRCA1-A, BRCA1-B, BRCA1-C, and the BRCA1/PALB2/BRCA2 complex, and plays diverse roles in a context-dependent manner. Among the complexes, BRCA1-A is critical for BRCA1 recruitment to the sites of DNA damage. Factors comprising the BRCA1-A include RAP80, CCDC98/Abraxas, BRCC36, BRCC45, BARD1, BRCA1, and MERIT40, a RAP80-associated factor. In this review, we summarize recent findings of the factors that form the BRCA1-A complex.
Publisher
OXFORD UNIV PRESS
ISSN
1672-9145
Keyword (Author)
BRCA1 complexesBRCA1RAP80MERIT40DNA damage
Keyword
DOUBLE-STRAND BREAKSUBIQUITIN E3 LIGASEHOMOLOGOUS RECOMBINATION REPAIRGENOMIC STABILITYTUMOR SUPPRESSIONS-PHASECHECKPOINT CONTROLBINDING DOMAINTARGETS BRCA1END RESECTION

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