BROWSE

Related Researcher

Author's Photo

Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

ITEM VIEW & DOWNLOAD

Netrin-1/DCC-mediated PLC gamma 1 activation is required for axon guidance and brain structure development

Cited 0 times inthomson ciCited 0 times inthomson ci
Title
Netrin-1/DCC-mediated PLC gamma 1 activation is required for axon guidance and brain structure development
Author
Kang, Du-SeockYang, Yong RyoulLee, CheolPark, BumWooPark, Kwang IlSeo, Jeong KonSeo, Young KyoCho, HyungjoonLucio, CoccoSuh, Pann-Ghill
Issue Date
2018-09
Publisher
WILEY
Citation
EMBO REPORTS, v.19, no.11, pp.1 - 11
Abstract
Coordinated expression of guidance molecules and their signal transduction are critical for correct brain wiring. Previous studies have shown that phospholipase C gamma1 (PLC gamma 1), a signal transducer of receptor tyrosine kinases, plays a specific role in the regulation of neuronal cell morphology and motility in vitro. However, several questions remain regarding the extracellular stimulus that triggers PLC gamma 1 signaling and the exact role PLC gamma 1 plays in nervous system development. Here, we demonstrate that PLC gamma 1 mediates axonal guidance through a netrin-1/deleted in colorectal cancer (DCC) complex. Netrin-1/DCC activates PLC gamma 1 through Src kinase to induce actin cytoskeleton rearrangement. Neuronal progenitor-specific knockout of Plcg1 in mice causes axon guidance defects in the dorsal part of the mesencephalon during embryogenesis. Adult Plcg1-deficient mice exhibit structural alterations in the corpus callosum, substantia innominata, and olfactory tubercle. These results suggest that PLC gamma 1 plays an important role in the correct development of white matter structure by mediating netrin-1/DCC signaling.
URI
https://scholarworks.unist.ac.kr/handle/201301/24862
URL
http://embor.embopress.org/content/early/2018/09/16/embr.201846250
DOI
10.15252/embr.201846250
ISSN
1469-221X
Appears in Collections:
UCRF_Journal Papers
SLS_Journal Papers
Files in This Item:
There are no files associated with this item.

find_unist can give you direct access to the published full text of this article. (UNISTARs only)

Show full item record

qrcode

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

MENU