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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 11 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | EMBO REPORTS | - |
dc.citation.volume | 19 | - |
dc.contributor.author | Kang, Du-Seock | - |
dc.contributor.author | Yang, Yong Ryoul | - |
dc.contributor.author | Lee, Cheol | - |
dc.contributor.author | Park, BumWoo | - |
dc.contributor.author | Park, Kwang Il | - |
dc.contributor.author | Seo, Jeong Kon | - |
dc.contributor.author | Seo, Young Kyo | - |
dc.contributor.author | Cho, Hyungjoon | - |
dc.contributor.author | Lucio, Cocco | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-21T20:14:48Z | - |
dc.date.available | 2023-12-21T20:14:48Z | - |
dc.date.created | 2018-09-17 | - |
dc.date.issued | 2018-09 | - |
dc.description.abstract | Coordinated expression of guidance molecules and their signal transduction are critical for correct brain wiring. Previous studies have shown that phospholipase C gamma1 (PLC gamma 1), a signal transducer of receptor tyrosine kinases, plays a specific role in the regulation of neuronal cell morphology and motility in vitro. However, several questions remain regarding the extracellular stimulus that triggers PLC gamma 1 signaling and the exact role PLC gamma 1 plays in nervous system development. Here, we demonstrate that PLC gamma 1 mediates axonal guidance through a netrin-1/deleted in colorectal cancer (DCC) complex. Netrin-1/DCC activates PLC gamma 1 through Src kinase to induce actin cytoskeleton rearrangement. Neuronal progenitor-specific knockout of Plcg1 in mice causes axon guidance defects in the dorsal part of the mesencephalon during embryogenesis. Adult Plcg1-deficient mice exhibit structural alterations in the corpus callosum, substantia innominata, and olfactory tubercle. These results suggest that PLC gamma 1 plays an important role in the correct development of white matter structure by mediating netrin-1/DCC signaling. | - |
dc.identifier.bibliographicCitation | EMBO REPORTS, v.19, no.11, pp.1 - 11 | - |
dc.identifier.doi | 10.15252/embr.201846250 | - |
dc.identifier.issn | 1469-221X | - |
dc.identifier.scopusid | 2-s2.0-85053460576 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/24862 | - |
dc.identifier.url | http://embor.embopress.org/content/early/2018/09/16/embr.201846250 | - |
dc.identifier.wosid | 000449752600007 | - |
dc.language | 영어 | - |
dc.publisher | WILEY | - |
dc.title | Netrin-1/DCC-mediated PLC gamma 1 activation is required for axon guidance and brain structure development | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | MIDBRAIN DOPAMINERGIC-NEURONS | - |
dc.subject.keywordPlus | PHOSPHOLIPASE C-GAMMA-1 | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | NETRIN RECEPTOR | - |
dc.subject.keywordPlus | DCC | - |
dc.subject.keywordPlus | INNERVATION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | CIRCUITRY | - |
dc.subject.keywordPlus | KINASE | - |
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