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Choi, Jang Hyun
Lab of Diabetes and Metabolism (LDM)
Research Interests
  • Diabetes, Metabolic Disorders, PPARg, Gene Regulation, Anti-Diabetic Drug

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RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2

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Title
RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2
Author
Shin, YoonjaeKim, Yong WooKim, HyeminShin, NakyoungKim, Tae SungKwon, Taeg KyuChoi, Jang HyunChang, Jong-Soo
Issue Date
2018-09
Publisher
SPANDIDOS PUBL LTD
Citation
BIOMEDICAL REPORTS, v.9, no.3, pp.241 - 246
Abstract
Members of the Ras superfamily of small G-proteins serve as molecular switches of intracellular signaling pathways. Rac2 is a Rho subfamily GTPase switch that is specifically expressed in hematopoietic cells and regulates AKT activation in cell signaling. Ras activating protein-like 3 (RASAL3) is the recently identified Ras GTPase activating protein (GAP) that is also specifically expressed in hematopoietic cells and stimulates p21ras GTPase activity. The restricted expression of both Rac2 and RASAL3 suggests that they may serve critical roles in hematopoietic cell signaling. Here in the present study demonstrates that the catalytic domain of RASAL3 may also be able to interact with Rac2 and stimulate its GTPase activity in vitro. By contrast, p50 rhoGAP molecules did not markedly affect Rac2 GTPase activity, but did accelerate the activity of other Rho GTPases, including Rac1, RhoA and Cdc42. Collectively, the present results indicate, seemingly for the first time, that GAP activity for Rac2 is regulated by the RasGAP family protein, RASAL3.
URI
https://scholarworks.unist.ac.kr/handle/201301/24260
URL
https://www.spandidos-publications.com/10.3892/br.2018.1119
DOI
10.3892/br.2018.1119
ISSN
2049-9434
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BIO_Journal Papers
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